Program EAACI Summer School

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Summer School Course
September 26-30, 2004
Dubrovnik, Croatia

Under the Auspices of Ministry of Science, Education and Sports
Republic of Croatia


Croatian Society for Allergology and Clinical Immunology Croatian Medical Society

Zagreb, September 26th 2004

Dear colleagues and friends,

A warm welcome to Croatia and to the Summer School Course of GA2LEN and European Academy of Allergology and Clinical Immunology. The Local Organising Committee has done a good job in putting together a scientific programme, and at the same time offering an exciting social programme. GA2LEN, the Global Allergy and Asthma European Network, as a "Network of Excellence" include 25 leading European teams from sixteen European countries, in addition to EAACI and the patients association European Federation of Allergy and Airways Diseases (EFA). Reflecting on the growing concern about the rising rates of allergy and asthma GA2LEN and EAACI want to emphasize importance of health problems that require serious mobilization for prevention and effective treatment. GA2LEN invests in education in this Summer School in Cavtat/Dubrovnik in order to strengthen the interaction of young researchers and clinicians and, consequently, help in decreasing the burden of allergy and asthma throughout Europe. Dear colleagues and friends, enjoy these days in Croatia, have interesting event, and take something home!

Paul van Cauwenberge
Coordinator of GA2LEN project
European Academy of Allergology and Clinical Immunology

Dear friends, colleagues and distinguished guests,

We are very happy to seize this very opportunity to welcome you in here, in the Region of Dubrovnik on the occasion of Summer School Course of the GA2LEN program, and the European Academy of Allergology and Clinical Immunology.

I am especially pleased to welcome the Representative of Croatian Ministry of Science and Mr. Paul van Cauwenberge, the coordinator of the GA2LEN program. This city of Cavtat was the precursor to the historic city of Dubrovnik, which unifies culture, preservation of nature's beauty and the spirits of ancient Romans, Greeks and Croats. The foundations upon which The Republic of Dubrovnik was built are well suited to serve the ideas of GA2LEN project including unity across Europe and excellence in the art and science of allergy medicine.

Many generous spirits live around us. We are surrounded by the culture of the sea, travel, exploration and discovery. The painter Bukovac, scientists Bogišić and Bošković, poet Gundulić, they all descend from Dubrovnik, and their spirits supports us in our needs to understand, learn and build new ideas.

Many stories could be told about the importance of Dubrovnik in the history of trade, arts, commerce, architecture, but more than anything else I want to encourage you to discover with each other and for yourselves the mystery and beauty that this ancient city offers you.

We put together scientific program to update you on the most recent findings in allergy, but we also want you to take time to connect that new knowledge with an exploration of regional historic heritage.

Finally, I would like to thank to the Mr. Dragan Primorac, Croatian Minister of science, education and sports, as well as pharmaceutical companies Pliva, Astra-Zeneca, MSD and Lek for their generous support in sponsoring this meeting.

I wish to all of you enjoyable and productive days.

Asja Stipić Marković, MD
President of the Local Organizing Committee

Local organising Comittee
Asja Stipić Marković
Jadranka Morović Vergles
Nada Čikeš
Branimir Čvorišćec
Sanja Popović Grle
Alenka Gagro
Mirjana Turkalj
Boro Nogalo
Vedran Ostojić
Mira Radulović Pevec
Branko Pevec
Petar Pekić

Scientific Program Comittee
Claus Bachert (BE)
Carsten Bindslev-Jensen (DK)
Jean Bousquet (FR)
Peter Burney (UK)
Paul van Cauwenberge (BE)
Adnan Custovic (UK)
Stephen Durham (UK)
Tony Frew (UK)
Marek Kowalski (PL)
Jan Lötvall (SE)
Torsten Zuberbier (DE)
Magnus Wickman (SE)
Alenka Gagro (HR)
Asja Stipic Markovic (HR)
Jadranka Morovic Vergles (HR)
Mirjana Turkalj (HR)

Mira Radulović Pevec
Sveti Duh General Hospital
Sveti Duh 64
HR-10000 Zagreb, Croatia
Telephone: +385 1 3712230
Fax: +385 1 3712107

Web site and e-mail addresses

Summer School Venue

Summer school will be held in "Ragusa" Congress Room of Hotel "Croatia" in Cavtat. Cavtat rests at the very south of the Croatia; 18 kilometres from Dubrovnik and 6 kilometres from Dubrovnik International Airport. Cavtat was a Greek settlement known as Epidaurum. Among the attractions of Cavtat are the Rector's Palace, the Baroque church of St. Nikola, the Franciscan monastery, Bogišić's scientific collection, Vlaho Bukovac Art Gallery, Račić Mausoleum, designed by the famous Croatian sculptor Ivan Meštrović, archaeological sites of the pre-Slav period, city walls, the Šipun cave etc.

Hotel Croatia
Phone: +385 20 478555, 478055
Fax: +385 20 478213


Sunday 26th

Welcome Reception on the terrace of Hotel Croatia

Monday 27th

Peter Burney, United Kingdom
Epidemiological trends in allergic diseases

Jean Bousquet, France
The early development of allergy and the role of IgE

Coffee break

Alenka Gagro, Croatia
T-cells and antigen presenting cells in allergy

Torsten Zuberbier, Germany
Other regulatory cells in allergy, including mast cells

Jan Lötvall, Sweden
The truth and the proof about the eosinophil


Paul van Cauwenberge, Belgium
The innate immune system in allergy

Claus Bachert, Belgium
Bacteria and bacterial products in allergic organ disease

Coffee break

Carsten Bindslev Jensen, Denmark
Gastrointestinal manifestations in pollen allergy

Adnan Custovic, United Kingdom
Hygiene good or bad in allergy

Dinner in restaurant Konavoski dvori

Tuesday 28th

Magnus Wickman, Sweden
Primary and secondary prevention of allergy

Jean Bousquet, France
The link between the nose and the lung in allergy

Coffee break

Carsten Bindslev Jensen, Denmark
Linking atopic dermatitis and airway allergy


Jan Lötvall, Sweden
The bone marrow as a link in multiple organ allergy

Paul van Cauwenberge, Belgium
Neural factors in allergy


Magnus Wickman, Sweden
Future principles of treating allergic disease

Marek Kowalski, Poland
Pharmacology and pharmacogenetics in allergy

Coffee break

Adnan Custovic, United Kingdom
Indoor and outdoor allergens in different European areas

Visit to Gallery Bukovac, house Bogišić and pinacoteque of St. Nikola's church in Cavtat

Wednesday 29th

The Terrace Encounters - all faculty
Each of the faculty chair one table for informal discussions with 10-12 students. A "menu" listing the different items the professor could discuss directly with the students is presented at the table. The session is intended to be very interactive, and the students are requested to bring their own work, data, posters, slide presentations and manuscripts for discussion.

Boat trip to Dubrovnik. Tour to Rector's Palace, Franciscan Monastery, Cathedral and Sponza Palace. Dinner in traditional Restaurant.

Thursday 30th

Anthony Frew, United Kingdom
Clinical evidence of mechanisms of immunotherapy

Asja Stipić Marković, Croatia
Peptide immunotherapy

Coffee break

Jadranka Morović Vergles, Croatia
Complexity of immune response to common antigens compared to allergens; Sensitisation and tolerance

Anthony Frew, United Kingdom
Review of efficacy studies of immunotherapy

Mirjana Turkalj, Croatia
Pollen immunotherapy group discussion
Indoor allergen immunotherapy group discussion
Bee and wasp venom immunotherapy group discussion
Safety issues in immunotherapy group discussion
Alternative regimens for immunotherapy group discussion


Lunch / Closing
GA2LEN / EAACI Summer School's Social Events, Croatia 2004

Sunday 26th

On the terrace of the Hotel Croatia, which lies in a beautiful position, overlooking the Adriatic on one side and the picturesque old City of Cavtat on the other. The famous medieval walled City of Dubrovnik can be seen from there.

Monday 27th

This trip takes us to the heart of the Konavle Valley, in a village known for its carefully preserved folk customs, rich national costumes and famous embroidery. Dinner will follow at the restaurant Konavoski Dvori, proceeded by a traditional welcome of local brandy and dried figs.

Tuesday 28th

When in CAVTAT, one must visit:
- Mausoleum of the Račić family, an octagonal structure with a dome, a masterpiece by famous Croatian sculptor Ivan Meštrović (1883-1962)
- Art gallery of Vlaho Bukovac, famous Croatian painter, born in Cavtat in 1855
- The Franciscan Monastery and Baroque parish church of St. Nikola and the Pinotheque which holds treasury of rare paintings and ceremonial church decorations.
- Baldo Bogišić's (solicitor and writer from the 19th century) collection of works of art, graphics and library.

Wednesday 29th

This tour begins with a boat drive to the Dubrovnik Harbour, with view of the city walls and the picturesque surroundings. A pleasant walk through the city which is on UNESCO-s List of Cultural Heritage will take you to:
- Stradun, picturesque main street of the old city, which has remained virtually unchanged since the 13th century.
- Cathedral built in 1713 on the ruins of the unknown cathedral dating from the seventh century. The Cathedral Treasury is extraordinarily rich. Visitors will perhaps turn to the memorial tablet dedicated to Ragusa's great son, the famous scientist and writer Ruđer Bošković.
- Rector's Palace, constructed in 1435, also was a seat of government. The architecture combines Gothic and early Renaissance styles, and the palace today houses a museum with furnished rooms, historical exhibits, and baroque paintings.
- Franciscan Monastery, dating from the 14th century, with its impressive cloister, a rich library with a beautiful reading room, and a pharmacy that dates back to 1317. The church houses also the tomb of the poet Gundulić.
- Sponza Palace, one of the most beautiful buildings in the city, featuring a mix of late Gothic and early Renaissance styles, with impressive stone carvings, constructed in 1516. The atrium, with its arched galley, was said to have been the most lively commercial center and meeting place for businessmen and intellectuals.

Useful information

Travelling through Croatia, Dalmatia or Dubrovnik Region offers immense and rich experiences to every visitor.

The total land area of Croatia amounts to 56.610 km2, with a population of approximately 4.9 million. Spread like pearls along the coast, Croatia's 1.185 islands provide a magical paradise to be experienced and explored.

The capital of Croatia is Zagreb.

There are seven National Parks in Croatia, three being in the mountainous regions (Risnjak, Paklenica and Plitvička Jezera), and four in the coastal regions (Kornati, Brijuni, Krka and Mljet).


These days Croatia is rapidly improving its road infrastructure. Croatia is integrated into the European road marking system. European roads have the mark "E" and highway roads "M". The most picturesque route in Croatia is considered to be the Adriatic highway (Jadranska magistrala) which connects Rijeka and Dubrovnik.

Custom duties are not paid on personal objects. Professional and technical equipment of sustainable value should be reported upon entering Croatia. Foreign currency can be imported and exported freely.

Documents and regulations
There are several documents travellers need to have available on their trips across Croatia: a valid passport, a valid International driving license, the vehicle registration card and insurance. When entering Croatia, all damage on the vehicle must be reported at the border office. Once in Croatia, all tourists are required to register upon arrival at their destination. If you are staying in a hotel, private accommodation or camp this will generally be done automatically for you. Tourists may remain in Croatia for up to three months on their tourist visas.

Traffic regulations are similar to those enforced in other European countries. Croatia uses right-hand traffic with general speed limits of 100 km/h on overland roads, 130 km/h on motor ways and 50 km/h in built-up areas. While driving along the coast in Dubrovnik or the Dubrovnik Region, you may encounter many places where the speed limits are lowered.

The permissible alcohol limit is 0 (zero) promiles.

24-hour information is provided by the Croatian Automobile Club Information center, telephone +385 1 4640-800, web:

Gundulic's dream
by Vlaho Bukovac

Vlaho Bukovac (1855-1922), famous Croatian painter was born in Cavtat in 1855. In 1877 he arrived in Paris and entered the Ecole des Beaux Arts, in Cabanel's class. After completing his studies, he moved between Paris, Cavtat, Dubrovnik, Cetinje, Split, and Korčula, painting numerous portraits and compositions on various topics.
Bukovac has moved to Zagreb in 1893 and started an important era in Croatian painting. From this time come his major compositions such as "Gundulic's Dream", Dubravka and the curtain for the Croatian National Theatre. He founded the Association of Croatian Artists. In 1898, the Bukovac family went to Prague, where artist became a professor at the Prague Academy of arts. His picture "The Development of Croatian Culture" was put up in the National and University Library.

Ivan Gundulić (1589-1638) was primarily a writer. He wrote lyric poems and a number of plays. As a man of his period, Gundulic was convinced that all the things of his world are transient, that all pleasures are evanescent, that it is necessary to concentrate all one's thoughts on religion. This conviction especially pervades Suze sina razmetnoga (The tears of the prodigal son) and his longest work, poem Osman. He captured Dubrovnik's sense of freedom in the 17th century: "Oh, you beautiful, oh dear; oh, you sweet freedom; all the silver, all the gold, all human lives cannot be a price for your eternal beauty."

Croatian Society for Allergology
and Clinical Immunology
Croatian Medical Society